Yes, in Settings › Appearance. It has four sections: Colors, Layout, Reading and Date & time. Every choice applies to all accounts and folders and can be changed at any time.
Colors holds light or dark mode and the colour palette — Indigo, a cool ink with indigo accents, or Graphite, warm neutrals with a soft violet accent. Email content has its own theme setting beside it, so you can keep a dark app and still read messages on white.
Layout is where the workspace is shaped: the mail view (a message list, or the chat-style conversation view), the reading pane beside the list or below it, message rows on two lines or a single line, the sidebar stacked / split / as an account switcher, its density comfortable or compact, and whether an account’s backup badge sits on the avatar, at the end of the row, or is hidden.
Reading covers conversations — Grouped collapses replies into one row, Expandable unfolds them in the list, Off gives every message its own row — along with thread order, signature handling, row highlighting and action-button style.